Toremifene Dosage
In addition, these differences in response are not limited to the dose of toremifene, but also affect its general effectiveness.
Toremifene was only officially approved for use in 1997, so as of the date of this profile (2013), it has only been used in clinical and medical settings for 16 years.
Even then, it didn't begin to be used in the anabolic steroid-using community until the early to mid-2000s, when bodybuilders and athletes began to take notice.
In comparison, Nolvadex has been used and studied extensively in the medical community for over 50 years, and its uses and results are well established.
While Toremifene has been found not to exhibit certain properties that Nolvadex is known for (such as liver carcinogenic effects or a dramatic decrease in IGF-1 levels with prolonged use), this does not mean for one moment that Toremifene does not exhibit these effects.
For all intents and purposes, Toremifene is a very closely related sibling drug to Nolvadex, and it is very possible that these effects have not yet been documented when taking Toremifene.
In general, the dosage of Toremifene should be much higher than that of its most similar ingredient, Nolvadex.
Of course, the dosage of Toremifene also depends on the intended use.
Anabolic steroids used by bodybuilders and athletes have two main uses for Toremifene and Toremifene dosage, one is to mitigate, block, or prevent gynecomastia, and the second is to restore endogenous testosterone production during PCT after an anabolic steroid cycle has ended.
One of the advantages of the lower potency and effectiveness of Toremifene compared to Nolvadex is that there is greater room for dose adjustment.
For example, the dose of toremifene needed to treat gynecomastia is much lower than the dose of toremifene needed to restore HPTA function.
This is discussed in more detail in this section of the profile.
Before describing the details of use and dosage, the reader should be made aware of the following important points
The use of SERMs or anti-estrogens should only be used when absolutely necessary, and should be discontinued as soon as the requirement for use (such as gynecomastia or low androgen production) disappears.
Medical Toremifene Dosage
Toremifene (Fareston) is used medically and clinically for the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive (or estrogen receptor-unknown) tumor growth.
The medical dose of toremifene for this purpose is 60 mg per day.
Most clinical studies (including animal studies) conducted in breast cancer patients have used medical doses of toremifene ranging from 30 to 60 mg per day.
In any case, most prescription toremifene products contain 60 mg tablets.
Toremifene Dosage During Anabolic Steroid Use
Due to the nature of the compound, it is not possible to categorize Toremifene into the usual 3 tiers (beginner, intermediate, advanced).
This is typically broken down in most profiles for other anabolic steroids and other performance enhancing drugs.
Toremifene in particular is not typically used for the sole (or direct) purpose of enhancing physique or athletic performance, and is instead known as a secondary ancillary compound.
As an ancillary compound, Toremifene is used by anabolic steroid users to mitigate a number of undesirable side effects caused by the excessive production of estrogen during anabolic steroid use.
In some ways, Toremifene can be said to enhance athletic performance to some extent due to its endogenous testosterone boosting effects via HPTA stimulation.
However, taking Toremifene for this purpose is unlikely to result in significant changes in performance or physique.
In this case, the protocol for taking Toremifene is best used during post cycle therapy (PCT) to restore HPTA and endogenous hormone function.
For the purpose of alleviating gynecomastia (preventing, treating, palliating, or otherwise): When using aromatizing anabolic steroids for the prevention of gynecomastia, the required dose of toremifene is 30 to 60 mg per day.
If gynecomastia is beginning to form or has already formed, a stronger toremifene dose of 120 mg per day is recommended until gynecomastia symptoms subside.
If gynecomastia has already developed or is in progress, it is recommended that you take toremifene in combination with an aromatase inhibitor for maximum effectiveness.
One important point to note is that while Nolvadex has been proven to negatively affect IGF-1 levels during use, this effect has not yet been demonstrated in clinical studies with Toremifene.
For this reason, it is not recommended to take Nolvadex chronically and daily during a cycle, as it can cause a dramatic decrease in IGF-1 levels, which is a very important anabolic hormone and can affect potential gains during a cycle.
However, it is important to keep in mind that Toremifene is an almost identical sibling compound to Nolvadex and is very likely to exhibit the same activity in the body and has not yet been found in clinical studies.
While Toremifene may have a much smaller effect on IGF-1 levels than Nolvadex, increasing the dose of Toremifene may have the same effect.
Also, since Toremifene increases SHBG levels, which decreases total free testosterone in the body, it is not recommended to administer more than the minimum necessary during a cycle[1].
Female Toremifene Dosage
Female anabolic steroid users do not have to worry about the development and growth of breast tissue (gynecomastia) and therefore do not need to take Toremifene.
The only notable use of Toremifene in women is for the treatment of female breast cancer patients, as mentioned in the medical Toremifene dosage section above.
Toremifene Dosage for Increased Endogenous Testosterone Secretion and Post Cycle Therapy (PCT)
The beneficial effects of toremifene dosage on HPTA and endogenous testosterone production in men have been demonstrated in clinical studies.
As discussed in the introduction to this profile, this is a result of the antagonistic action of toremifene on the hypothalamus, where it binds to estrogen receptors located in the hypothalamus.
As a result, the hypothalamus mistakenly believes that there is a severe lack of estrogen in the bloodstream and responds by signaling the pituitary gland to increase production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
These two hormones signal the Leydig cells in the testes to start producing testosterone, which increases the aromatization of testosterone to restore the estrogen levels that the hypothalamus has been 'tricked' into thinking are low.
The result is increased testosterone production and enhanced function of HPTA.
However, the dose of Toremifene required for this purpose is much higher than the dose of Toremifene required to alleviate or block gynecomastia.
Studies have shown that a daily dose of 60 mg of toremifene increased testosterone levels in subjects by 42%[2].
While this is a significant increase, it is much lower than the standard 20 mg daily dose of Nolvadex, which increased testosterone levels by 71% in the same study.
Therefore, it was determined that Toremifene is not as potent as Nolvadex for this purpose, and instead the dosage of Toremifene to more effectively increase testosterone production should be in the range of 120 mg per day.
This dosage can be maintained throughout the 4-6 week PCT period, although some anabolic steroid users choose to reduce the dosage (e.g. 120 mg/day for the first week of PCT, 100 mg/day for the second week, and 60 mg/day for the remaining 3-4 weeks).
It is also highly recommended to combine Toremifene with HCG and an aromatase inhibitor for a more effective and complete PCT protocol (see the Post Cycle Therapy article for more information).
Proper dosing and timing of Toremifene
There are no special considerations regarding dosing and timing of Toremifene.
Toremifene can be administered before, during, or after meals.
It can also be taken in the morning or at night before bed.
The half-life of toremifene is 5 days, which is long enough to maintain stable blood levels for 24 hours (or longer) without having to split the tablet or dose, so it is not necessary to spread your dose of toremifene throughout the day.
Expected effects and results of taking toremifene
Toremifene is used to prevent, relieve, or block the development of gynecomastia.
For this purpose, it is recommended to treat gynecomastia immediately when it begins to develop or to use it for prevention.
It is also useful for stimulating natural endogenous testosterone production after an anabolic steroid cycle has been discontinued, especially if the function of the HPTA has been inhibited or disrupted due to the use of exogenous androgens.
For this purpose, Toremifene can be used for hormonal restoration.
Toremifene related references
[1] Effects of Toremifene on Endocrine Regulation in Breast Cancer Patients. Számel I, Hindi I, Vince B, Eckhardt S, Cangas L, Hajbar A. Eur J Cancer. 1994;30A(2):154-8.
[2] Effect of selective estrogen receptor modulator administration on the hypothalamic-pituitary-testicular axis in men with idiopathic oligozoospermia. Tsourdi E, Kourtis A, Farmakiotis D, Katsikis I, Salmas M, Panidis D. Fertil Steril. 2009 Apr;91(4 Suppl):1427-30. doi: 10.1016/j.fertnstert.2008.06.002. Epub 2008 Aug 9.
